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The Influence of Dietary Fats on the Adenosine Diphosphate Induced Platelet Thrombosis in the Rat
Author(s) -
Nordöy A.,
Chandler A. B.
Publication year - 1964
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1964.tb00016.x
Subject(s) - linseed oil , platelet , thrombosis , adenosine diphosphate , medicine , endocrinology , cholesterol , platelet aggregation , body weight , chemistry , food science
1 A thrombotic state, elicited by adenosine diphosphate, was induced in the rat by dietary saturated fats and cholesterol, and was intensified by propylthiouracil. 2 ADP‐induced platelet thrombosis occurred without evidence of prior vascular disease, and the diets alone did not induce thrombosis. 3 Unsaturated fat (linseed oil) in the amounts used, did not significantly affect the incidence of thrombosis. 4 The mortality to ADP was reduced in all female animals supplemented by linseed oil in the diet. 5 The LD 50 of ADP given intravenously to male rats was found to be 16.6 mg per 100 g body weight.