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Trisomy 8 in myeloid leukemia cutis confirmed by fluorescence in situ hybridization analysis
Author(s) -
Shvartsbeyn Marianna,
Meehan Shane M.,
Gu Ping,
Nierodzik Mary Lynn,
Perle Mary Ann
Publication year - 2012
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2012.01981.x
Subject(s) - leukemia cutis , fluorescence in situ hybridization , myeloid leukemia , trisomy , pathology , trisomy 8 , leukemia , in situ hybridization , aneuploidy , interphase , fish <actinopterygii> , medicine , biology , cytogenetics , cancer research , immunology , chromosome , genetics , fishery , gene , gene expression
We present a case of a 64‐year‐old man with refractory acute myeloid leukemia and trisomy 8 who developed leukemia cutis. Interphase fluorescence in situ hybridization ( FISH ) was performed on a paraffin‐embedded skin section. FISH confirmed a population of cells with trisomy 8 in the blastic infiltrates involving the skin. This case illustrates a novel application of interphase FISH to confirm the diagnosis of leukemia cutis.
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