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Sinonasal non‐keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation
Author(s) -
Guo Ruifeng,
Metcalf Sara,
Neil Crowson A.
Publication year - 2012
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2012.01939.x
Subject(s) - pathology , malignancy , medicine , histopathology , biopsy , basal cell , context (archaeology) , presentation (obstetrics) , radiology , biology , paleontology
Sinonasal non‐keratinizing squamous cell carcinoma ( SCC ), previously designated as transitional cell carcinoma or cylindrical cell carcinoma, is an uncommon malignant neoplasm with distinct histopathological features, considered to be a low‐grade malignancy that usually occurs in elderly patients. Extensive local invasion is uncommon. Here we report a case of 90‐year‐old woman whose original presentation was as erythematous nasal skin nodules, biopsy of which showed a dermal tumor with features of sinonasal non‐keratinizing SCC . No epidermal dysplasia was present. A subsequent computed tomography scan confirmed the presence of an endophytic tumor on the nasal sidewall. The initial presentation of sinonasal non‐keratinizing SCC as a skin lesion is previously unreported to our knowledge. Diagnosis in this context requires accurate evaluation of the histopathology as well as a comprehensive knowledge of pathology specific to this anatomic location.