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Indolent CD8‐positive T‐cell lymphoid proliferation of the ear: a report of two cases
Author(s) -
Zeng Weifen,
Nava Victor E.,
Cohen Philip,
Ozdemirli Metin
Publication year - 2012
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2012.01917.x
Subject(s) - lymphoma , cd8 , granzyme b , cytotoxic t cell , pathology , medicine , lymphatic system , t cell , t cell lymphoma , immunology , biology , antigen , immune system , biochemistry , in vitro
The current classification of primary cutaneous T‐cell lymphoma (CTCL) of the World Health Organization (WHO) includes primary cutaneous CD8‐positive aggressive epidermotropic cytotoxic T‐cell lymphoma as a provisional entity awaiting cumulative data. Recent reports identify CD3/CD8‐positive clonal T‐cell lymphoid proliferations arising in the ear and nose that behave indolently and therefore defy currently established subclassification. Here, we report two cases of clonal CD8‐positive/granzyme‐B‐negative T‐cell lymphoid proliferations that arose in the ear and behaved indolently. Collectively, these cases suggest that an additional category of cutaneous indolent CD8‐positive T‐cell lymphoma may be necessary among the existing classification schemes. Zeng W, Nava VE, Cohen P, Ozdemirli M. Indolent CD8‐positive T‐cell lymphoid proliferation of the ear: a report of two cases.