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Azathioprine‐induced EBV‐positive mucocutaneous ulcer
Author(s) -
McGinness Jamie L.,
Spicknall Kerith E.,
Mutasim Diya F.
Publication year - 2012
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2011.01829.x
Subject(s) - mucocutaneous zone , medicine , azathioprine , histopathology , dermatopathology , pathology , dermatology , disease
Epstein‐Barr virus (EBV)‐positive mucocutaneous ulcer was recently described as a clinicopathologic entity occurring secondary to iatrogenic or age‐related immune suppression. The histopathology of EBV‐positive mucocutaneous ulcer reveals a polymorphous infiltrate including atypical large B‐cells and Reed‐Sternberg‐like cells which are CD20‐positive, CD30‐positive and EBV‐positive. The disorder follows an indolent and self‐limited course. We report a case of EBV‐positive mucocutaneous ulcer secondary to prolonged use of azathioprine for the treatment of pemphigoid and highlight the need for recognition of this disorder by dermatopathologists and dermatologists. McGinness JL, Spicknall KE, Mutasim DF. Azathioprine‐induced EBV‐positive mucocutaneous ulcer.
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