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Multicentric reticulohistiocytosis and urologic carcinomas: a possible paraneoplastic association
Author(s) -
Tan Belinda H.,
Barry Catherine I.,
Wick Mark R.,
White Kevin P.,
Brown Jeffrey G.,
Lee Abigail,
Litchfield Amy H.,
Lener Elizabeth V.,
Shitabata Paul K.
Publication year - 2011
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2010.01608.x
Subject(s) - medicine , pathology , histiocytosis , pathophysiology , pathogenesis , langerhans cell histiocytosis , disease
Multicentric reticulohistiocytosis (MR) is a rare non‐Langerhans histiocytosis that is characterized by cutaneous nodules and severe destructive arthritis. Although 25–30% of reported cases have been associated with internal malignancies, the pathophysiology of MR is unknown. Herein, we report two cases of MR that were associated with urologic neoplasms. Because the tumor suppressor gene p53 may play a role in the biology of other histiocytoses, we investigated its p53 immunoexpression in these two cases. Both cases were positive immunohistochemically, but it remains to be seen whether this finding is truly important in the pathogenesis of MR associated with underlying visceral neoplasms. Tan BH, Barry CI, Wick MR, White KP, Brown JG, Lee A, Litchfield AH, Lener EV, Shitabata PK. Multicentric reticulohistiocytosis and urologic carcinomas: a possible paraneoplastic association.