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Findings of osseous sclerotic bodies: a unique sequence of cutaneous bone formation in nephrogenic systemic fibrosis
Author(s) -
Kartono Francisca,
Basile Amy,
Roshdieh Babak,
Schwimer Christopher,
Shitabata Paul K.
Publication year - 2011
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2010.01591.x
Subject(s) - nephrogenic systemic fibrosis , pathology , fibrosis , medicine , sequence (biology) , anatomy , biology , magnetic resonance imaging , radiology , genetics
Nephrogenic systemic fibrosis (NSF) is a progressive and potentially fatal fibrosing skin disorder found mainly in patients with renal insufficiency. NSF is characterized by thickened and hyperpigmented skin lesions with or without systemic involvement. In essentially all patients, this disease entity has been associated with the administration of gadolinium contrast agents for imaging purposes. Microscopic recognition of this entity remains challenging, as the diagnosis is based on various clinical and histopathologic features that overlap with other fibrosing disorders. No single feature is absolutely specific for NSF. We report a finding of osseous sclerotic bodies with elastin trapping appearing on histopathology in the clinical setting of NSF with hemodialysis‐dependent renal failure. Our report of an additional attribute indicative of NSF may aid in making the diagnosis. Kartono F, Basile A, Roshdieh B, Schwimer C, Shitabata PK. Findings of osseous sclerotic bodies: a unique sequence of cutaneous bone formation in nephrogenic systemic fibrosis.