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Sarcomatoid renal cell carcinoma presenting in the oropharynx
Author(s) -
Gammon Bryan Leigh,
Gleason Briana C.,
Thomas Antoinette B.,
Cibull Thomas Lee
Publication year - 2010
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2010.01578.x
Subject(s) - renal cell carcinoma , pathology , malignancy , medicine , metastasis , clear cell renal cell carcinoma , lesion , clear cell , carcinoma , immunohistochemistry , cancer
Metastasis stemming from a distant malignancy is far less common than an oropharyngeal primary and represents only 1% of all oral neoplasms. The difficulty in diagnosing a metastasis in the oropharynx may be compounded if the lesion is poorly differentiated and bears little resemblance to the primary tumor. We present the case of synchronous metastatic renal cell carcinoma of the mandibular gingiva in a woman with sarcomatoid clear cell renal cell carcinoma. The metastatic lesion was poorly differentiated and lacked expression of the renal cell carcinoma (RCC) antigen. In contrast, PAX‐8 staining was strongly positive. This case serves to highlight the diagnostic difficulty posed by poorly differentiated lesions in the oropharynx and reinforces the sensitivity of the cell lineage‐specific transcription factor PAX‐8 in poorly differentiated RCC. Gammon BL, Gleason BC, Thomas AB, Cibull TL. Sarcomatoid renal cell carcinoma presenting in oropharynx.