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Nodular spindle cell proliferation in the wall of a varicose vein mimicking Kaposi's sarcoma
Author(s) -
ValBernal José Fernando,
Val Daniel,
Garijo María Francisca,
GómezRomán José Javier
Publication year - 2011
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2010.01547.x
Subject(s) - pathology , sarcoma , spindle cell sarcoma , anatomy , kaposi's sarcoma , medicine , hemosiderin , biology , human herpesvirus
Exuberant reparative reactions resembling sarcoma have been reported in the genitourinary tract, thyroid, breast, lymph node, oral cavity and skin, but not in a varicose vein. Presented herein is the case of a 55‐year‐old man who showed an incidental nodular lesion in the wall of a varicose vein on the left leg. The nodule consisted of fascicles of spindled cells with ovoid or elongated nuclei and delicate chromatin that showed diffuse reactivity for CD31, alpha‐smooth muscle actin and D2‐40. This histopathological appearance, when coupled with extravasated erythrocytes and interstitial hemosiderin deposits, resembled Kaposi's sarcoma or spindle cell angiosarcoma. Key features helpful for recognizing that the proliferation we describe is a form of tissue repair include an association with obvious hemorrhage; lack of well‐formed curved fascicles of spindled cells; lack of intracytoplasmic hyaline globules; lack of intracellular vacuolization; cytological blandness; low mitotic count; absence of inmmunoreactivity for human herpesvirus‐8 (HHV‐8) latent nuclear antigen‐1; and absence of HHV‐8 in polymerase chain reaction (PCR) analysis. Val‐Bernal JF, Val D, Garijo MF, Gómez‐Román JJ. Nodular spindle cell proliferation in the wall of a varicose vein mimicking Kaposi's sarcoma.