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Fibrofolliculoma with ancient/pseudosarcomatous features
Author(s) -
Cesinaro Anna Maria,
Rusev Borislav Chavdarov,
Kutzner Heinz
Publication year - 2010
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2009.01453.x
Subject(s) - factor xiiia , pathology , cd34 , lesion , immunohistochemistry , stromal cell , medicine , population , dermis , dermatofibrosarcoma protuberans , anatomy , biology , stem cell , microbiology and biotechnology , environmental health
Fibrofolliculoma is a benign skin lesion that, when multiple, can be part of the Birt‐Hogg‐Dube syndrome. We report on a case of solitary fibrofolliculoma arisen on the nose of a 63‐year‐old woman, with peculiar histological and immunohistochemical features. The lesion was characterized by the presence of bizarre multinucleated perifollicular stromal cells, positive for factor XIIIa, in a background of CD34‐positive cells, and by a peripheral population of CD34‐positive spindle cells organized in fascicles haphazardly infiltrating the deep dermis, and surrounded by scattered factor XIIIa‐positive dendrocytes. We consider the bizarre perifollicular cellular component as an ‘ancient’ feature of fibrofolliculoma, hypothesis corroborated by the co‐expression of CD34 and factor XIIIa, whereas the peripheral spindle cell fascicles represent a pseudosarcomatous proliferation of CD34‐positive cells, normally surrounding adnexal structures, stimulated by factor XIIIa‐positive dendrocytes. Cesinaro AM, Rusev BC, Kutzner H. Fibrofolliculoma with ancient/pseudosarcomatous features.