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Papular mycosis fungoides: two new cases of a recently described clinicopathological variant of early mycosis fungoides
Author(s) -
MartorellCalatayud Antonio,
BotellaEstrada Rafael,
SanmartínJimenez Onofre,
Requena Celia,
GuillénBarona Carlos,
Sangüeza Omar Pastor
Publication year - 2010
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2009.01417.x
Subject(s) - mycosis fungoides , lymphomatoid papulosis , medicine , pathology , dermatology , cutaneous t cell lymphoma , peripheral t cell lymphoma , immunohistochemistry , lymphoma , t cell , immunology , immune system
Background: Mycosis fungoides (MF) is the most common type of cutaneous T‐cell lymphoma. In early stages of the disease many different clinicopathologic variants have been observed. Currently, a papular variant of MF which is characterized by a good prognosis has been described. Objective and Methods: Because only seven cases have been reported in the literature, clinical and morphological data of this variant are not well established. We report the clinical and histopathological characteristics of two new patients with papular mycosis fungoides and review the previous cases reported in the literature. Results: The two cases of this early variant of MF were characterized by the presence of papules which, unlike the papules of lymphomatoid papulosis, did not show a tendency for spontaneous resolution. Histologic examination confirmed the diagnosis of MF in all cases. Immunohistochemical staining for CD30 was negative in all two cases. Follow‐up data of our two patients confirmed the non‐aggressive behavior of the disease, confirming that the lesions were not manifestations of advanced MF. Conclusion: Papular MF is a new variant of early MF characterized by a good prognosis in the long term follow‐ up. Thus, it should be added to the long list of clinicopathologic subtypes of MF. Martorell‐Calatayud A, Botella‐Estrada R, Sanmartín‐Jimenez O, Requena C, Guillén‐Barona C, Sangueza OP. Papular mycosis fungoides: two new cases of a recently described clinicopathological variant of early mycosis fungoides.