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Multiple cutaneous monoclonal B‐cell proliferations as harbingers of systemic angioimmunoblastic T‐cell lymphoma
Author(s) -
Bayerl Michael G.,
Hennessy Jeannie,
Ehmann William Christopher,
Bagg Adam,
Rosamilia Lorraine,
Clarke Loren E.
Publication year - 2010
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2009.01408.x
Subject(s) - lymphoma , angioimmunoblastic t cell lymphoma , monoclonal , pathology , b cell , clone (java method) , medicine , cell of origin , follicular lymphoma , large cell , monoclonal antibody , immunology , t cell , biology , cancer , antibody , adenocarcinoma , dna , immune system , genetics
We describe a 66‐year‐old man initially diagnosed with primary cutaneous marginal zone B‐cell lymphoma who developed four additional monoclonal/monotypic B‐cell lymphoid proliferations and a systemic angioimmunoblastic T‐cell lymphoma over the course of 19 months. Through retrospective analysis, we identified the evolution of a T‐cell clone within the background of clinically and pathologically dominant cutaneous B‐cell tumors. In terms of clinical practice, this case supports that patients diagnosed with multiple clonal B‐cell proliferation need thorough investigation and close clinical follow up to identify a coexistent or evolving systemic lymphoma, in particular, peripheral T‐cell lymphomas of follicular T‐helper cell type, such as angioimmunoblastic T‐cell lymphoma. Biologically, this case offers unique insight into the interactions between B‐cell and T‐cell lineages in lymphoid neoplasia. Bayerl MG, Hennessy J, Ehmann WC, Bagg A, Rosamilia L, Clarke LE. Multiple cutaneous monoclonal B‐cell proliferations as harbingers of systemic angioimmunoblastic T‐cell lymphoma.