Premium
Scleromyxedema with an interstitial granulomatous‐like pattern: a rare histologic variant mimicking granuloma annulare
Author(s) -
Rongioletti Franco,
Cozzani Emanuele,
Parodi Aurora
Publication year - 2010
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2009.01386.x
Subject(s) - pathology , granuloma annulare , medicine , reticular dermis , demodex , granuloma , incontinentia pigmenti , reticular connective tissue , morphea , biopsy , dermis , dermatology , biology , botany , mite
Scleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76‐year‐old man presenting with scleromyxedema associated with IgGλ monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous‐like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition. Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous‐like pattern: a rare histologic variant mimicking granuloma annulare.