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Histiocytic erythema multiforme
Author(s) -
Sebastian Anita,
Patterson Connor,
Zaenglein Andrea L.,
Ioffreda Michael D.,
Helm Klaus F.
Publication year - 2009
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2009.01287.x
Subject(s) - erythema multiforme , pathology , histiocyte , medicine , erythema , cd68 , dermatology , biopsy , skin biopsy , immunohistochemistry
Erythema multiforme is histologically characterized by liquefactive degeneration along the dermal‐epidermal junction, necrotic keratinocytes and a lymphocytic infiltrate. We report a 10‐year‐old boy with recurrent erythema multiforme major of undetermined etiology with unusual histologic findings. A skin biopsy taken at day 2 of his eruption revealed histologic features otherwise characteristic of erythema multiforme, but mediated instead by a CD68‐positive infiltrate, resembling cutaneous Kikuchi's disease. To the best of our knowledge this is the first reported case of ‘histiocytic’ erythema multiforme.