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Histiocyte‐rich pleomorphic mastocytoma: an uncommon variant mimicking juvenile xanthogranuloma and Langerhans cell histiocytosis
Author(s) -
Tran Don T.,
Jokinen Chris H.,
Argenyi Zsolt B.
Publication year - 2009
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2009.01257.x
Subject(s) - juvenile xanthogranuloma , pathology , histiocyte , cd68 , birbeck granules , histiocytosis , mastocytoma , giant cell , epithelioid cell , medicine , neurofibroma , atypia , immunohistochemistry , langerhans cell , biology , neurofibromatosis , immunology , antigen , disease , cancer research , tumor cells
An 11‐year old Caucasian female with a remote history of urticaria pigmentosa presented with a neck mass. A biopsy demonstrated a large intradermal nodule composed of unusually large epithelioid mast cells, including a prominent subset with bi‐lobed and multi‐lobed nuclei. By immunohistochemistry, the cells expressed CD117 (C‐Kit), mast cell tryptase, CD68, and CD25, and were negative for CD163, CD1a, and S‐100, confirming the diagnosis of mastocytoma. Equally prominent was an admixed infiltrate of CD68 and CD163‐positive xanthomatous histiocytes that included Touton‐type giant cells. Eosinophils were abundant. At 7 months follow‐up, there was no recurrence of the lesion following complete excision. However, given the unusual cytologic features, close clinical observation is warranted, as the long‐term biologic potential of mastocytoma with this degree of cytologic atypia is uncertain. Awareness of this unusual morphologic variant is also important as the histologic features may mimic such childhood neoplasms as juvenile xanthogranuloma and Langerhans cell histiocytosis.