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An infiltrative variant of non‐neural granular cell tumor: a case report
Author(s) -
Yeh Iwei,
Tran Don T.,
Davis Thomas L.,
Argenyi Zsolt B.
Publication year - 2009
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2008.01214.x
Subject(s) - pathology , granular cell tumor , pleomorphism (cytology) , biology , granular cell , merkel cell , immunohistochemistry , merkel cell carcinoma , medicine , carcinoma , neuroscience , central nervous system
Dermal non‐neural granular cell tumors are rare tumors of indeterminate lineage that typically present as well‐circumscribed tumors with nuclear pleomorphism and mitotic activity. We describe a dermal non‐neural granular cell tumor with a distinctive growth pattern with granular cells interspersed between collagen bundles. This asymptomatic papule arose on the scapula of a 46‐year‐old woman and consisted of a mixture of epithelioid and spindled granular cells. The immunohistochemical characteristics were similar to those of previously reported dermal non‐neural granular cell tumors. Despite mild nuclear pleomorphism and dispersion of lesional cells among collagen bundles, mitoses were not present and Ki‐67 staining indicated a low proliferative rate. In addition to being S‐100 protein negative and NKI/C3 positive, our case was positive for PGP9.5 and weakly positive for neuron‐specific enolase, a staining pattern similar to what has been observed for cellular neurothekeomas. Our case could represent a dermal non‐neural granular cell tumor with unique architecture, a granular cellular neurothekeoma or a granular cell dermatofibroma. As both dermal non‐neural granular cell tumor and cellular neurothekeoma are of indeterminate lineage, our case with features characteristic of both entities may suggest a common precursor or lineage for dermal non‐neural granular cell tumor and cellular neurothekeoma.