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Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson’s disease patients and its relation to dyshidrosis
Author(s) -
Kawada Morihiro,
Tamada Yasuhiko,
Simizu Hirokazu,
Yanagishita Takeshi,
Yamashita Noriko,
Ishida Natsuko,
Watanabe Daisuke,
Yoshida Mari,
Ibi Tatsu,
Sahashi Kou,
Hashizume Yoshio,
Matsumoto Yoshinari
Publication year - 2009
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2008.01086.x
Subject(s) - vasoactive intestinal peptide , sudomotor , axon reflex , medicine , sweat , etiology , neuropeptide , immunohistochemistry , pathology , reflex , receptor
Background: With regards to dyshidrosis in Parkinson’s disease (PD), there is no established and consistent view on the occurrence sites, frequency and etiology, although there have been several reports on hypohidrosis of the limbs and sudoresis on the face/cervical region. Methods: Hydrosis in the forearms of PD patients and healthy individuals were compared by quantitative sudomotor axon reflex test (QSART). The expression of various neuropeptides and α‐synuclein was examined with immunohistochemical staining. Results: There was a significant reduction in QSART of PD patients but not of healthy controls. Reduced expression of vasoactive intestinal polypeptide (VIP) was also detected in the sweat glands of PD patients. Conclusion: Reduction in QSART and VIP expression in the sweat glands might be involved in the dyshidrosis of PD patients.