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Nevi with site‐related atypia: a review of melanocytic nevi with atypical histologic features based on anatomic site
Author(s) -
Hosler Gregory A.,
Moresi Jean Margaret,
Barrett Terry L.
Publication year - 2008
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2008.01041.x
Subject(s) - atypia , pathology , medicine , nevus , melanoma , malignancy , melanocytic nevus , dermatology , nuclear atypia , seborrheic keratosis , immunohistochemistry , cancer research
A subset of melanocytic nevi share features with melanoma and nevi with architectural disorder but are biologically inert and to date do not appear to portend an increased risk for the development of malignancy. These benign nevi with certain atypical histologic features cluster among specific anatomic sites and are thus designated nevi with site‐related atypia. We categorize these lesions into four main groups: acral, genital, special site and conjunctival, based on anatomy and relative prevalence of specific atypical histologic features. As the literature and our recognition of these lesions continue to grow, our understanding of their biology has not kept pace.