Premium
Atrophoderma of Pasini and Pierini: a clinical and histopathological study
Author(s) -
Saleh Zenus,
Abbas Ossama,
Dahdah Maurice J.,
Kibbi Abdul G.,
Zaynoun Shukrallah,
Ghosn Samer
Publication year - 2008
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2008.00986.x
Subject(s) - morphea , trunk , medicine , histology , pathology , dermatology , biopsy , biology , ecology
Background: Idiopathic atrophoderma of Pasini and Pierini (IAPP) usually manifests as one or multiple depressed and hyperpigmented patches, with a predilection to the trunk. No diagnostic changes are usually seen on histology. Elastic stains often reveal no abnormalities. Objective: To review our cases of IAPP, describe their clinical and histological findings and compare them with the literature. Methods: Retrospective review of IAPP cases who presented to our institution between 1994 and 2006. Results: From a total of 16 patients, only 19% displayed hyperpigmented lesions, while 81% had either hypopigmented (9/16) or skin‐colored (4/16) lesions. The sites predominantly affected were the lower extremities (62.5%), followed by the upper extremities and trunk. Only in one patient was IAPP co‐existent with morphea. Histology revealed no diagnostic abnormalities; however, elastic stains showed a spectrum of changes ranging from normal to severe diminution and fragmentation of elastic fiber network. Conclusions: Our study shows several new aspects of IAPP. Clinically, the lesions were most commonly hypopigmented and involved predominantly the extremities. Histologically, IAPP exhibited a spectrum of alterations in elastic fibers. The most prevalent form of IAPP in our country seems to be unassociated with morphea.