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Delayed reaction after an octopus bite showing a giant cell‐rich granulomatous dermatitis/panniculitis
Author(s) -
Misago Noriyuki,
Inoue Takuya,
Narisawa Yutaka
Publication year - 2008
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2007.00947.x
Subject(s) - panniculitis , giant cell , papule , medicine , pathology , epithelioid cell , nodule (geology) , dermatology , granuloma annulare , granuloma , lesion , biology , immunohistochemistry , paleontology
Adequate clinical data and a sufficient workup, in addition to the histopathological findings, are frequently required to make a correct diagnosis of granulomatous dermatitis/panniculitis. These lesions with an unexpected etiology may include delayed hypersensitivity granulomatous reactions to various factors, such as metals or marine animal injuries. A 50‐year‐old male presented with multiple subcutaneous nodules on his right forearm 1 month following an octopus bite at his right wrist. After the disappearance of these lesions, which responded well to low‐dose oral prednisone, another type of skin lesion characterized by small, numerous papules reappeared on his right forearm. Histopathologically, a specimen from a subcutaneous nodule showed mostly lobular granulomatous panniculitis, which showed an extensive diffuse infiltrate composed of numerous multinucleated giant cells and epithelioid cells intermingling with lymphocytes and eosinophils. A specimen from a papule that subsequently developed disclosed a diffuse granulomatous dermatitis composed of similar cells and also showed granuloma annulare‐like features. This case is considered to be a delayed reaction after an octopus bite showing an unusual giant cell‐rich granulomatous dermatitis/panniculitis. Octopus bites should therefore be included among the marine animal injuries, which cause a delayed‐type reaction with granulomatous dermatitis/panniculitis.