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Transformation of cutaneous gamma/delta T‐cell lymphoma following 15 years of indolent behavior
Author(s) -
Hosler Gregory A.,
Liégeois Nanette,
Anhalt Grant J.,
Moresi J. Margaret
Publication year - 2008
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2007.00931.x
Subject(s) - lymphoma , immunophenotyping , medicine , panniculitis , pathology , aggressive lymphoma , cutaneous lymphoma , biopsy , t cell lymphoma , clone (java method) , dermatology , mycosis fungoides , immunology , biology , rituximab , dna , flow cytometry , genetics
Subcutaneous gamma/delta (γ/δ) T‐cell lymphoma is a rare lymphoma, characterized by its unique immunophenotype and clinical course. It has been shown to behave more aggressively than its counterpart bearing the α/β receptor and has recently been removed from the subcutaneous panniculitis‐like T‐cell lymphoma category for this very reason. We present a case of a patient with a 15‐year running diagnosis of panniculitis. Following these years of indolent behavior, the disease began an aggressive clinical course and she was diagnosed with γ/δ T‐cell lymphoma. Molecular analysis identified a T‐cell clone, which through retrospective analysis, was also shown to be present in the patient’s original biopsy material. We present this case as a rare example of initial indolent behavior in a lymphoma typically considered very aggressive.