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Folliculosebaceous cystic hamartoma or trichofolliculoma? A spectrum of hamartomatous changes inducted by perifollicular stroma in the follicular epithelium
Author(s) -
Wu YuHung
Publication year - 2008
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2007.00914.x
Subject(s) - stroma , pathology , hamartoma , epithelium , medicine , follicular phase , immunohistochemistry
Background: Folliculosebaceous cystic hamartoma (FSCH) histologically resembles trichofolliculoma. Methods: The clinical and histologic characteristics of both tumors were studied retrospectively, comparing these findings with those of other similar follicular tumors described in the literature. Results: Fourteen cases of FSCH and 15 cases of trichofolliculoma were diagnosed over 5 years. FSCH were larger, of longer duration, located mostly in the head and neck region. Histologically, the two lesions had a similar architecture except for the presence of a secondary follicle in trichofolliculoma. Conclusion: FSCH are probably more common than previously thought and may be part of a spectrum of cystic follicular tumors. The perifollicular stroma may influence differentiation of the cystic wall, resulting in a variety of follicular tumors with overlapping features.