Premium
Myopericytoma: report of two cases associated with trauma
Author(s) -
Laga Alvaro C.,
Tajirian Ani L.,
Islam Mohammed N.,
Bhattacharyya Indraneel,
Cohen Donald M.,
Plamondon Caroline J.,
RobinsonBostom Leslie
Publication year - 2008
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2007.00910.x
Subject(s) - angioleiomyoma , medicine , pathology , anatomy , soft tissue , glomus tumor , hemangiopericytoma , malignancy , nose , biopsy , smooth muscle tumor , leiomyoma
Myopericytoma is a rare, recently described tumor demonstrating a hemangiopericytoma‐like vascular pattern. We present two cases of myopericytoma associated with trauma: a 64‐year‐old man who developed several nodules on his nose four months after sustaining multiple abrasions to his forehead and nose, and a 72‐year‐old woman with a solitary growth in the alveolar ridge of unknown duration. Biopsy specimens of the lesions in both cases demonstrated a striking concentric perivascular proliferation of bland spindle‐shaped pericytic cells characteristic of myopericytoma. Despite sharing morphologic features with angioleiomyoma, myofibroma and glomus tumor, myopericytoma is thought to represent a distinct perivascular myoid neoplasm of skin and soft tissues. The tumor is characterized by a radial and perivascular arrangement of ovoid, spindled to round neoplastic cells that are immunoreactive to alpha‐smooth muscle actin, often for h‐caldesmon as well as smooth muscle myosin‐heavy chain, and usually negative for desmin antibodies. Most cases of myopericytoma are benign, however, local recurrence and malignancy have recently been reported, Myopericytoma can be multifocal involving a single or multiple anatomic regions, and tends to occur in dermal and superficial soft tissues of adults primarily on the extremities. Our cases are unusual examples of myopericytoma manifesting as multiple nodules on the nose, and a solitary growth on the buccal mucosa after trauma.