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Atypical distinctive dermal clear cell mesenchymal neoplasm arising in the scalp
Author(s) -
Gavino Alde Carlo P.,
Pitha Jan V.,
Bakshi Nasir A.
Publication year - 2008
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2007.00823.x
Subject(s) - histogenesis , mesenchymal stem cell , pathology , pleomorphism (cytology) , neoplasm , stain , biology , scalp , clear cell , immunohistochemistry , anatomy , medicine , staining
Distinctive dermal clear cell mesenchymal neoplasm (DDCCMN) is a newly described entity characterized by a dermal proliferation of neoplastic cells with clear to reticulated cytoplasm and vesicular nuclei. Atypical features in the form of nuclear pleomorphism and mitoses may be found. The histogenesis of these neoplastic clear cells is not currently known but they are thought to be mesenchymal in origin. Immunohistochemically, they stain positively for NKI‐C3 and negatively for melanocytic, epithelial and lymphoid markers. All five cases originally reported by Lazar and Fletcher occurred in the lower extremities. We report herein a case of DDCCMN with atypical features arising in the scalp.