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Prominent Langerhans’ cell migration in the arthropod bite reactions simulating Langerhans’ cell histiocytosis
Author(s) -
Kim Se Hoon,
Kim Dong Hyun,
Lee Kwang Gil
Publication year - 2007
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2007.00751.x
Subject(s) - langerhans cell , langerhans cell histiocytosis , arthropod , dermis , immunohistochemistry , pathology , biology , dendritic cell , histiocytosis , infiltration (hvac) , antigen , medicine , immunology , paleontology , disease , physics , thermodynamics
Background: Epidermal Langerhans’ cells (LCs) play pivotal roles in cutaneous immune responses. An encounter with antigens or other stimuli causes the mobilization and migration of LCs. Therefore, some dermatoses, which originated from antigenic stimuli or trauma, can show LC migration. Recently, we experienced several cases of anthropod bites that showed marked inflammatory infiltrates with eosinophils and CD1a‐positive LCs. It was difficult to differentiate these cases from Langerhans’ cell histiocytosis (LCH). Methods: The degree and pattern of LC infiltration in the skin of arthropod bite reaction was evaluated. The characteristics of CD1a immunohistochemical expression in the arthropod bite reactions were compared with those of LCH. Results: A few arthropod bite cases (approximately 36%) showed extensive CD1a‐positive LCs in the dermis, especially in the perivascular area. In addition, the CD1a expression patterns of LCs in the arthropod bite reactions were dendritic, whereas that of tumor cells in LCH were distinctly membranous and cytoplasmic. Conclusion: Some arthropod bite reactions can show marked CD1a‐positive LCs in the dermis, especially in the perivascular area. The dendritic CD1a immunohistochemical staining pattern in arthropod bite reactions is useful in helping to differentiate from LCH.