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Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis
Author(s) -
Bhattacharjee Pradip,
Glusac Earl J.
Publication year - 2007
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2006.00723.x
Subject(s) - pathology , scabies , langerhans cell histiocytosis , histiocytosis , cd30 , medicine , immunohistochemistry , hyperplasia , dermatology , disease
Aim: In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under‐recognized that scabies can also mimic Langerhans cell histiocytosis. Methods: Sixteen examples of scabies were reviewed histologically and immunohistochemically (CD1a, CD3, CD20, CD30 and S100). Results: Immunohistochemical labeling showed florid CD1a and S100 positivity in most cases, indicative of Langerhans cell hyperplasia. Scattered CD30+ lymphocytes were also typically present, within a dense infiltrate, primarily composed of T lymphocytes and eosinophils. Conclusion: Because of the prominent CD1a+/S100+ component, scabies can mimic Langerhans cell histiocytosis. This finding should be considered in conjunction with scattered CD30+ cells and clinical features to avoid misdiagnosis.