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Skeletal muscle regeneration: report of a case presenting as a cutaneous nodule following blunt trauma to the lip
Author(s) -
Ghosn Samer H.,
Radfar Arash,
Stefanato Catherine M.
Publication year - 2007
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2006.00617.x
Subject(s) - nodule (geology) , desmin , pathology , skeletal muscle , biopsy , regeneration (biology) , immunoperoxidase , medicine , rhabdomyosarcoma , blunt trauma , muscle biopsy , anatomy , immunohistochemistry , biology , sarcoma , vimentin , radiology , monoclonal antibody , antibody , paleontology , immunology , microbiology and biotechnology
Skeletal muscle (SM) regeneration is a pleomorphic yet benign reaction pattern that follows injury to SM and has been reported to simulate histologically various malignancies such as squamous cell carcinoma and rhabdomyosarcoma. A 61‐year‐old man presented with a 4‐month history of an enlarging nodule on the upper lip following blunt trauma. An initial punch biopsy was non‐diagnostic. A deeper biopsy revealed a multilobular proliferation of atypical and pleomorphic cells with vesicular nuclei, prominent nucleoli, and large amphophilic cytoplasm. Immunoperoxidase studies showed these cells to be positive for muscle‐specific actin and desmin and negative for S‐100 protein and smooth muscle actin. Based on these findings, a diagnosis of skeletal muscle regeneration (SMR) was made. To our knowledge, this is the first report of SMR presenting clinically as a rapidly growing cutaneous nodule on the lip following blunt trauma.