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Expression of BMI‐1 in normal skin and inflammatory and neoplastic skin lesions
Author(s) -
Reinisch Christina M.,
Uthman Aumaid,
Erovic Boban M.,
Pammer Johannes
Publication year - 2007
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2006.00587.x
Subject(s) - pathology , hair follicle , outer root sheath , downregulation and upregulation , basal (medicine) , immunohistochemistry , epidermis (zoology) , biology , oncogene , stem cell marker , stem cell , keratinocyte , cell , medicine , endocrinology , microbiology and biotechnology , cell culture , cell cycle , anatomy , biochemistry , genetics , gene , insulin
Background: BMI‐1 is involved in the maintenance of stem cells and functions as an oncogene in both lymphomas and solid carcinomas, acting by downregulation of p16ink4a. We have investigated the expression profile of BMI‐1 in normal and inflamed skin as well as in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs). Methods: BMI‐1 expression was determined by immunohistochemistry and immunofluorescence, and evaluated semiquantitatively. Results: BMI‐1 was weakly expressed in nuclei of basal and sometimes suprabasal keratinocytes, in basal cells of sebaceous glands, weakly to moderately in the bulge area and the external root sheath of hair follicles, and strongly in sweat glands. Whereas BCCs showed strong and diffuse BMI‐1 expression, SCCs expressed BMI‐1 heterogeneously. Strong cytoplasmic expression of BMI‐1 was found in dividing cells. Conclusions: BMI‐1 expression marks stem cells within the hair follicle. As BMI‐1 was also found in suprabasal keratinocytes and a variety of specialized cells, the distribution of BMI‐1 only partly reflects the known distribution of stem cell compartments. BMI‐1 is strongly overexpressed in BCCs, tumors linked to dysregulation of the sonic hedgehog pathway, which has been shown to upregulate BMI‐1 , suggesting a contribution of the BMI‐1 oncogene in their pathogenesis.