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Expression of class II β‐tubulin in non‐melanoma cutaneous tumors
Author(s) -
Roh JooYoung,
Kee SunHo,
Choi JungWoo,
Lee JiHye,
Lee JuHan,
Lee Eung Seok,
Kim YoungSik
Publication year - 2007
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2006.00583.x
Subject(s) - outer root sheath , pathology , tubulin , follicular phase , biology , immunohistochemistry , microtubule , hair follicle , grading (engineering) , medicine , microbiology and biotechnology , endocrinology , ecology
Background: Different combinations of β‐tubulin isotypes contribute to the diverse functions of microtubules (MTs). Class II β‐tubulin (class II tubulin) is up‐regulated in differentiated keratinocytes. In contrast, the expression of class II tubulin in follicular differentiation and cutaneous tumors has not been studied. Methods: The immunohistochemical expression of class II tubulin was investigated in 117 cutaneous tumors: 30 squamous cell carcinomas (SCCs), seven keratoacanthomas (KAs), 57 basal cell carcinomas (BCCs), 23 trichoepitheliomas (TEs), and in the adjacent non‐neoplastic skin. Results: Class II tubulin was expressed in the keratinocytes of the granular layer, melanocytes, hair cortical and cuticular cells, inner root sheath (IRS), companion layer (CL) of the outer root sheath (ORS), and mesenchymal cells with Schwannian or myogenic differentiation. Moreover, class II tubulin expression was increased in the areas of squamous or follicular differentiation in cutaneous tumors. On grading the follicular differentiation or myofibroblastic response with anti‐class II tubulin, TE showed follicular differentiation more frequently (p < 0.001) with less of a myofibroblastic response (p = 0.001) than BCC. Conclusions: Class II tubulin expression is closely related to squamous or follicular differentiation and may be helpful in distinguishing most SCCs from KAs and BCC from TE. However, it does not reliably distinguish well‐differentiated, crateriform SCC from KA.