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Non‐infectious granulomatous dermatitis: a clinicopathological study
Author(s) -
Mohan Harsh,
Bal Amanjit,
Dhami G. P.
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2006.00566.x
Subject(s) - medicine , granuloma annulare , granuloma , sarcoidosis , epithelioid cell , pathology , dermatology , etiology , pathological , rheumatoid nodule , disease , immunohistochemistry
Background: Granulomatous dermatitis frequently presents a diagnostic challenge to dermatopathologists because an identical histologic picture is produced by several causes, and conversely, a single cause may produce varied histologic patterns. Methods: A retrospective analysis of skin biopsies received over a period of 7 years was performed, and cases of non‐infectious granulomatous dermatitis diagnosed on histopathological examination were retrieved. Results: Out of a total of 586 cases of granulomatous dermatitis, 71 cases (12.11%) were categorized as non‐infectious granulomatous dermatitis on the basis of clinicopathological findings. Further subcategorization was done based on morphology of granulomas as epithelioid granulomas; 15 cases of sarcoidosis, 21.1%, one case of Crohn’s vulvitis, 1.4%, necrobiotic granulomas; 11 cases of granuloma annulare, 15.4%, two cases of rheumatoid nodule, 2.8%, 10 cases of foreign body granulomas, 14.0%; 32 cases of miscellaneous group, 45%. Conclusions: Morphology alone is seldom specific and cannot be used as a diagnostic tool for identification of specific diseases. Adequate clinical data and work up in combination of pathological resources can help in elucidation of specific etiology of granulomatous dermatitis.