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Primary cutaneous histiocyte and neutrophil‐rich CD30 + and CD56 + anaplastic large‐cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman
Author(s) -
Boudova Ludmila,
Kazakov Dmitry V.,
Jindra Pavel,
Sima Radek,
Vanecek Tomáš,
Kuntscher Vilem,
Vera Vozobulova,
Bouda Jiri,
Michal Michal
Publication year - 2006
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2006.00488.x
Subject(s) - cd30 , pathology , anaplastic large cell lymphoma , medicine , vincristine , histiocyte , lymphoma , prednisone , chemotherapy , cyclophosphamide
Background: Cutaneous lymphomas co‐expressing CD56 and CD30 are very rare. They share a clinicopathological overlap with natural killer‐ (NK)/T‐cell lymphomas and anaplastic large‐cell lymphomas (ALCLs), two entities with widely disparate clinical behavior. Methods: We present a case of an immunocompetent 57‐year‐old Caucasian woman with a rapidly growing, angiodestructive and neuroinvasive primary cutaneous ALCL (PCALCL). The neoplastic population of large anaplastic CD30 + and CD56 + T cells was masked by a massive admixture of histiocytes and neutrophils. The partially ulcerated and pus‐secreting tumor involved the forehead and scalp and was assessed as clinical stage IAE. Results: After chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone), the patient achieved a complete remission. Additionally, high‐dose chemotherapy with autologous peripheral blood stem‐cell transplantation was administered as a consolidation of complete remission, in which she has remained for 6 years. Conclusions: This is the first CD30 + and CD56 + primary skin lymphoma to be reported on the head. The presented case carries a remarkable combination of clinicopathological features of PCALCL and NK‐/T‐cell lymphoma.