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Vasculitis‐induced membranous fat necrosis
Author(s) -
Ramdial Pratistadevi K.,
Chetty Runjan
Publication year - 1999
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1999.tb01865.x
Subject(s) - vasculitis , pathology , medicine , adipose tissue , fat necrosis , pathological , systemic vasculitis , necrosis , pathogenesis , disease
Membranous fat necrosis (MFN) a distinct degenerative process of adipose tissue, is characterised by the presence of membranocystic lesions (MCLs) superimposed on a background of typical traumatictype fat necrosis. MCLs are cysts, of varying size and shape, thai are lined by an eosinophilic, crenulated membrane, having the staining properties of ceroid. Although MFN has been documented in varying systemic adipose tissue sites and in tumours, the pathogenesis of this pathological curiosity is unknown. To date, an ischemic basis for MFN has been the most proximate, and atherosclerosis and venous insufficiency, due to large and medium vessel disease, have been the most popular underlying clinical disorders. Although systemic vasculitis has been quoted as the underlying ischemic disorder in some patients, vasculitis has not been commented on nor demonstrated in tissue sections in association with MFN. In reporting vasculitis‐induced MFN, we document the occurrence of MFN in association with uncommon causes of vasculitis, namely: 1) Granulomaious vasculitis in a post‐herpetic zosteriform scar; 2) Cytoinegalovirus‐induced vasculitis in tie clinical setting of systemic lupus crythematosus; and 3) Lymphocytic vasculitis in a tetanus toxoid immunization site reaction.