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In vivo abnormal keratinization in Darier‐White's disease as viewed by real‐time confocal imaging
Author(s) -
González Salvador,
Rubinstein Gennady,
Mordovtseva Veronica,
Rajadhyaksha Milind,
Anderson R. Rox
Publication year - 1999
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1999.tb01797.x
Subject(s) - pathology , acantholysis , acanthosis , darier's disease , dyskeratosis , confocal , keratin , confocal microscopy , medicine , darier disease , hyperkeratosis , biology , disease , geometry , mathematics , antibody , immunology , autoantibody , microbiology and biotechnology
Darier‐White's disease is a rare autosomal‐dominant disorder of keratinization. The underlying pathology for the clinical presentation is acantholysis, and various types of dyskeralosis and acanthosis. In this study, we utilized a non‐invasive optical imaging modality, confocal reflectance microscopy, to identify specific histologic features of Darier‐White's disease in vivo . Micro graphic findings in the confocal images were corps ronds, suprabasal clefts, acantholytic suprabasal keratinocytes, and villi. Real‐time confocal images are illustrative and can be well correlated with known light microscopic phenomena, particularly in the case of keratinization abnormalities in Darier‐White's disease.