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Subcutaneous panniculitis‐like T‐cell lymphoma: further evidence for a distinct neoplasm originating from large granular lymphocytes of T/NK phenotype
Author(s) -
Dargent JeanLouis,
Roufosse Candice,
Delville JeanPierre,
Kentos Alain,
Delplace Jérôme,
Kornreich Anne,
Cochaux Pascale,
Hilbert Pascale,
Pradier Olivier,
Feremans Walter
Publication year - 1998
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1998.tb01764.x
Subject(s) - cytotoxic t cell , lymphoma , granzyme , cd8 , pathology , natural killer cell , antigen , granzyme b , biology , phenotype , cd3 , neoplasm , virus , perforin , immunology , medicine , gene , biochemistry , in vitro
We report the case of a 20 year‐old caucasian woman who presented a primary subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) as an invasive tumor of the chest wall. Herein, the neoplastic cells were found to express a CD3+CD8+ phenotype but also displayed variably the natural killer (NK)‐associated antigens CD56 and CD57 as well as granzyme B. On cytological examination, these cells showed a large granular lymphocyte (LGL)‐like morphology with presence of azurophilic granules in their cytoplasm. Electron dense and membrane bound granules like those found in cytotoxic T lymphocytes (CTL) were also demonstrated by electron microscopy. Neither rearrangement of the T‐cell receptor subunits nor Epstein‐Barr virus (EBV) genome was observed at the molecular level. The LGL‐like features of the neoplastic cells found in this case and the presence of NK‐associated antigens provide additional support to the cytotoxic derivation of most SPTCL.