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Solitary subcutaneous mucinosis surrounded by bizarre‐shaped, factor XIIIa‐positive cells with intranuclear vacuoles
Author(s) -
Terui Tadashi,
Aiba Setsuya,
Tagami Hachiro
Publication year - 1998
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1998.tb01732.x
Subject(s) - factor xiiia , mucinosis , pathology , vacuole , medicine , dermatopathology , dermatology , anatomy , immunohistochemistry , biology , cytoplasm , microbiology and biotechnology
We describe a subcutaneous mucinosis developing in the right cheek of a 38‐year‐old man. Histologic examination revealed bipolar fibroblast‐like cells embedded in a well demarcated mucinotis stroma in the stibcutis without a manifest reticulin network. In addition, bizarre, sometimes multinucleate, cells with intra‐nuclear vacuoles were found at the periphery of the mucinous stroma. Immunohistologically, both the bipolar fibroblastic cells and bizarre‐shaped cells were positive for vimentin, but were negative for smooth nuiscle A‐actin, desmin, CD34, S‐100, trypsin, or chymotrypsin. However, the latter reacted to anti‐factor XIIIa antibody, suggesting that they are derived from dermal dendritic cells. We think that this solitary subcutaneous mucinosis is a unique variant of cutaneous focal mucinosis, because neither a reticulin network nor reactivity to anti‐smooth muscle A‐actin antibody were demonstrable.