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Dermal infiltrate of enlarged macrophages in patients receiving chemotherapy
Author(s) -
Valks Ruud,
Vargas Erich,
Muñoz Elia,
FernándezHerrera Jesus,
GarciaDiéz Amaro,
Fraga Javier
Publication year - 1998
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1998.tb01730.x
Subject(s) - medicine , chemotherapy , maculopapular rash , pathology , granulocyte colony stimulating factor , granulocyte macrophage colony stimulating factor , rash , cytokine , dermatology , immunology
A histologically distinct maculopapular eruption has heen associated with the use of recombinant forms of granulocyte and gran‐ulocytte‐inacrophage colony‐stimulating factors (GCSF and GMCSF). One of the most distinctive features was an increase in the number and the size of dermal maerophages, which was proposed as a clue to diagnosis of these cytokine‐induced dermatoses. We describe 8 patients who received chemotherapy and who developed a maculopapular eruption, of which histological examination showed an increase in the numher and the size of dermal maerophages. Three patients had also received GM‐CSF or G‐CSF, before the onset of rash, but 5 patients had not. In conclusion, an increase in the number and the size of dermal macrophages is not specific for the reaction to GM‐CSF or G‐CSF, and may also be observed in patients receiving chemotherapy.