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Stimulation of folliculo‐sebaceous proliferations by neurofibromas: a report of two cases
Author(s) -
Rio Emilio,
Yus Evaristo Sánchez,
Simón Pilar,
Veiga Hugo A. Vázquez
Publication year - 1998
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1998.tb01724.x
Subject(s) - pathology , neurofibromatosis , stroma , comedo , neurofibroma , major duodenal papilla , biology , anatomy , hamartoma , medicine , dermatology , immunohistochemistry , cancer , breast cancer , ductal carcinoma , genetics
Two unrelated patients, a woman aged 44 and a man aged 56, with a type I neurofibromatosis, showed comedo‐like formations at the top of some neurofibromas. One of them was excised in each case and they were studied histopathologically. The comedo‐like formation of the first case mimicked the epithelial component of a fibrofolliculoma, and that of the second case had the structure of a primary late microcomedo and showed also anagen hair differentiation in the form of a follicular bulb and papilla. Both events are considered to be the result of a stimulation phenomenon and to reflect the essential role of the stroma in many cutaneous epithelial hyperplasias, hamartomas and possibly in some neoplasms.