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Staining of eccrine and apocrine neoplasms and metastatic adenocarcinoma with IKH‐4, a monoclonal antibody specific for the eccrine gland
Author(s) -
Ishihara Masabiko,
Mehregan Darius R.,
Hashimoto Ken,
Yotsumoto Shinichi,
Toi Yoichiro,
Pietruk Teresa,
Mehregan Amir H.,
Mehregan David A.
Publication year - 1998
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1998.tb01697.x
Subject(s) - apocrine , pathology , eccrine sweat gland , adenocarcinoma , medicine , adenoma , papillary adenocarcinoma , carcinoma , hidradenoma , sweat gland , cancer , sweat
The histogenesis of apocrine and eccrine neoplasms has always interested dermatopathologists. In addition, the histologic differential diagnosis of eccrine carcinoma from metastatic adenocarcinoma is of practical importance. We describe a novel monoclonal antibody IKH‐4 which stains the eccrine secretory coil, but not the apocrine secretory segment. Positive staining was observed in eccrine hidradenoma, eccrine poroma, eccrine spiradenoma, papillary eccrine adenoma, eccrine hidrocystoma, syringoma, eccrine carcinoma, and in 1 case of syringocystadenoma papilliferum. Negative staining was observed in apocrine adenocarcinoma, hidradenoma papilliferum, erosive adenomatosis of the nipple, and primary and metastatic adenocarcinomas. IKH‐4 antibody was useful in differentiating eccrine from apocrine neoplasms and in differentiating eccrine carcinoma from metastatic adenocarcinomas.