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Effects of topical calcipotriol on the expression of adhesion molecules in psoriasis
Author(s) -
Savoia Paola,
Novelli Mauro,
Matteis Antonietta,
Verrone Anna,
Bernengo Maria Grazia
Publication year - 1998
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1998.tb01695.x
Subject(s) - calcipotriol , psoriasis , pathology , medicine , immunohistochemistry , cell adhesion molecule , integrin , tenascin , extracellular matrix , dermatology , fibronectin , biology , immunology , microbiology and biotechnology , receptor
Seven patients with chronic plaque psoriasis were treated with topical calcipotriol for 8 to 24 weeks; the lesions improved in 5 patients. Immunohistochemistry was performed on frozen sections, to evaluate the expression of adhesion molecules and extracellular matrix components before and after therapy. Changes in expression and topography of β and β4 integrins were found on psoriatic lesions before therapy and a reduction in the expression of tenascin was detected as well. Moreover, several activation markers such as ICAM‐1, HLA‐DR, CD26 were focally positive, with a diffuse cytoplasmic reactivity, in basal and suprabasal layers in untreated lesions. In the 5 patients in whom lesions regressed after topical calcipotriol treatment, we observed a histological normalization of the epidermis and the inflammatory infiltrate was reduced. Moreover, not only was there a normalization in the expression and topography of adhesion molecules, but also the integrin pattern observed after therapy was superimposable to that of normal skin.