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Perineurial cell tumor (perineurioma) with granular cells
Author(s) -
DíazFlores L.,
AlvarezArgüelles H.,
Madrid J. F.,
Varela H.,
Gonzalez MaP.,
Gutierrez R.
Publication year - 1997
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1997.tb01463.x
Subject(s) - pathology , granular cell tumor , granular cell , medicine , immunohistochemistry , central nervous system
A form of benign cutaneous tumor with perineurioma findings and with the presence of associated granular cells is described. The two cases studied consisted of whorls made up of a high number of circumferentially arranged flattened cells, with perineurial characteristics, including bipolar cell processes, pinocytotic vesicles, a basal lamina, a positive immunoreactivity for EMA, and absence of immunostaining for S‐100 protein. The granular cells, enclosed within the whorls, contained densely packed vesicles, particles with an apparently solid core, as well as membrane‐limited vacuoles with disintegrating cellular organelles and electron‐dense amorphous material. While failing to demonstrate any immunoreactivity for EMA, the granular cells showed positivity for S‐100 protein, which supports their Schwann‐cell origin. Due to its morphological and immunohistochemical characteristics, this peculiar form of tumor can be considered as a perineurioma with perineurial cell whorls and granular cell changes occurring in associated Schwann cells at the center of the whorls.