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Less expression of cyclin E in cutaneous squamous cell carcinomas than in benign and premalignant keratinocytic lesions
Author(s) -
Bito Toshinori,
Ueda Masato,
Ito Akiro,
Ichihashi Masamitsu
Publication year - 1997
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1997.tb00796.x
Subject(s) - carcinogenesis , cyclin d1 , pathology , actinic keratosis , cyclin d , immunohistochemistry , cyclin b , cyclin b1 , seborrheic keratosis , cyclin e , cyclin , keratinocyte , cancer research , cell cycle , biology , cancer , medicine , basal cell , cyclin dependent kinase 1 , cell culture , genetics
In a previous study, we showed that overexpression of cyclin D, a G1 cyclin, is frequently associated with keratinocyte carcinogenesis as an early event. Another G1 cyclin, cyclin E, was recently suggested to be a prognostic marker for breast cancer. In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic kaeratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Positive cells were seen rarely in normal epidermis, in 9 of 20 cases of SK, in 5 of 6 cases of KA, in 9 of 13 cases of AK and in all 27 cases of BD. Some of the cases of AK and BD had positive cells in the superficial epidermis, where atypicality is less obvious. In contrast, positive cells were seen in 4 of 25 cases of SCC and none of 15 cases of BCC. These results suggest that expression of cyclin E plays a role in the formation of benign and premalignant keratinocytic tumors, whereas down‐regulation of cyclin E expression may be involved in carcinogenesis in human keratinocytes.