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Focal necrotizing panniculitis and vascular necrosis in rats given subcutaneous injections of cocaine hydrochloride
Author(s) -
Scott Danny W.,
Morrell Joan I.,
Vernotica Ellen M.
Publication year - 1997
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1997.tb00781.x
Subject(s) - necrosis , medicine , panniculitis , pathology , saline , subcutaneous injection , subcutaneous tissue , lesion , anesthesia
Subcutaneous injections of cocaine hydrochloride in sterile physiological saline were administered to rats at a dosage of 20 or 40 mg. kg −1 . Resultant skin lesions included focal areas of alopecia (within 1 to 2 days) which progressed to necrosis (within 2 to 7 days). Histologically, the skin lesions were characterized by necrotizing panniculitis and vascular necrosis, with only small numbers of inflammatory cells. The lesions may be ischemic in nature, and associated with cytotoxic properties of cocaine.