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Induction of psoriasiform inflammation by a bacterial superantigen in the SCID‐hu xenogeneic transplantation model
Author(s) -
Boehncke WolfHenning,
Zollner Thomas Matthias,
Dressel Daniela,
Kaufmann Roland
Publication year - 1997
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1997.tb00778.x
Subject(s) - superantigen , psoriasis , medicine , immunology , inflammation , pathogenesis , lymphocyte , pathology , immune system , t cell
Psoriasis is a chronic skin disease affecting about 2% of the Caucasian population, characterized by co‐existing inflammation and epidermal hyperproliferation. A T‐lymphocyte‐mediated autoimmune reaction induced by bacterial superantigens might be central in its pathogenesis. To model psoriasiform inflammation, we transplanted clinically uninvolved skin from psoriatic patients onto SCID mice. Repetitive intradermal injections with a bacterial superantigen and simultaneous intraperitoneal injections with the patients' superantigen‐stimulated peripheral mononuclear blood cells resulted in an inflammatory reaction exhibiting some of the hallmarks of psoriasis, e.g. epidermal hy‐perproliferation, papillomatosis, focal neo‐expression of ICAM‐1, and an exocytotic T‐lymphocytic infiltrate characterized by the expression of the cutaneous lymphocyte‐associated antigen. These observations document the potential of superantigens to trigger psoriasiform dermatitis and provide a model to study lymphocyte homing.