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Solitary reticulohistiocytoma in pregnancy: Immunohistochemical and ultrastructural study of a case with unusual immunophenotype
Author(s) -
Hunt Steven J.,
Shin Sung S.
Publication year - 1995
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1995.tb01404.x
Subject(s) - pathology , birbeck granules , immunophenotyping , enolase , immunohistochemistry , vimentin , histogenesis , biology , dermis , medicine , antigen , immunology , langerhans cell
A case of a solitary reticulohistiocytoma during pregnancy is reported. The tumor arose on the right thigh of a 31‐year‐old woman during the 2nd month of gestation. Physical examination 6 months later revealed a 9 × 6 mm yellowish white papule. A biopsy showed a dermal proliferation of spindle to polygonal cells embedded in fibrous tissue with admixed neutrophils, eosinophils, and lymphocytes. Immunohistochemistry was positive for S‐100, factor XIIIa, HLA‐DR, KP‐1, vimentin, and neuron‐specific enolase. Ultrastructurally, the cells showed abundant lipid, lysozomes, and endoplasmic reticulum. No Birbeck granules could be identified. The results suggest an aberrant immunophenotype intermediate between indeterminate cells and dermal dendritic cells. The relationship of these lineages to reticulohistiocytoma and other dermal proliferative disorders is reviewed.