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Ultrastructural spectrum of cutaneous nerve sheath myxoma/cellular neurothekeoma
Author(s) -
Argenyi Z.B.,
Kutzner H.,
Seaba M.M.
Publication year - 1995
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1995.tb01396.x
Subject(s) - myxoma , nerve sheath , ultrastructure , pathology , anatomy , nerve sheath tumor , medicine , schwannoma , cardiology
The histogenesis of cutaneous nerve sheath myxoma (NSM)/ cellular neurothekeoma (CNT) is still controversial. In this study, we examined the ultrastructural features of 16 NSM (3 classical, 11 CNT, and 2 mixed NSM/CNT). We classified the cells into 4 groups ultrastructurally. Type 1 cells were un‐differentiated polygonal cells with ovoid nuclei, cytoplasmic microfilaments, and occasionally with microfilament‐associated dense bodies. In most cells, the cytoplasmic membrane showed focal membranous densities and occasional basal‐lamina‐like material. This cell type comprised approximately 90% of CNT. Type II cells were more differentiated, had ovoid or spindled shapes, were rich in intracytoplasmic filaments, and were surrounded by continous basal lamina. These cells were consistent with Schwann cells and were present in the classical and mixed forms of NSM, and in a single case of CNT. Type III cells had features of perineurial cells and were relatively rare in classical NSM. Type IV cells resembled fibroblasts and were encountered in all variants of NSM. These results support the‐view that 1) the classical NSM has neural (mainly Schwann cell) differentiation, 2) CNT is predominantly composed of undifferentiated cells with partial features of Schwann cells, smooth muscle cells, myofibroblasts and fibroblasts, suggesting a divergent differentiation, and 3) CNT and NSM represent a histologic spectrum, but in CNT, the neural features are not fully expressed.