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Neurotropic melanoma with prominent melanization
Author(s) -
Barnhill Raymond L.,
Bolognia Jean L.
Publication year - 1995
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1995.tb00762.x
Subject(s) - melanoma , pagetoid , melanin , pathology , microphthalmia associated transcription factor , medicine , melanocyte , infiltration (hvac) , context (archaeology) , dermatology , biology , cancer research , tyrosinase , paleontology , biochemistry , genetics , physics , enzyme , thermodynamics
Neurotropic melanoma has generally been described in the context of desmoplastic melanoma. The vast majority of melanomas displaying neurotropism contain relatively little or no melanin. Herein, we report an unusual case of neurotropic melanoma with prominent melanin content. The patient developed a tumor notable For pagetoid (superficial spreading) melanoma with partial regression and a deep component characterized by perineurial aggregates of melanophages and intraneural infiltration by melanoma cells. This case serves to alert dermatopathologists to the fact that the spectrum of neurotropic melanoma includes tumors with perineurial aggregates of pigment‐containing cells.