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Pleomorphic hamartoma of the subcutis:
Author(s) -
Shitabata Paul K.,
Ritter Jon H.,
Fitzgibbon James F.,
Dehner Louis P.,
Wick Mark R.
Publication year - 1995
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1995.tb00749.x
Subject(s) - desmin , pathology , vimentin , hamartoma , lesion , biology , anatomy , fibroma , immunohistochemistry , medicine
The authors report an example of an unusual subcuticular spindle cell tumor with histologic features which were most like those of “pleomorphic fibroma.” However, the tumor cells exhibited bifid differentiation immunohistologically, with conjoint reactivity for vimentin, S‐100 protein, Leu‐7 antigen (CD57), myelin basic protein, and desmin. A hamartomatous origin was favored for this lesion, given its overall morphologic features, circumscription, and apparently heterogeneous cellular lineages. Although speculative, it is thought that this unusual cutaneous mass may represent a subcuticular analogue of the benign Triton tumor (neuromuscular choristoma) of deep soft tissues.