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Syringolymphoid hyperplasia with alopecia
Author(s) -
Tomaszewski MariaMagdalena,
Lupton George P.,
Krishnan Jayashree,
Welch Mark,
James William D.
Publication year - 1994
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1994.tb00722.x
Subject(s) - mycosis fungoides , lymphocytic infiltration , pathology , hyperplasia , biopsy , medicine , hairless , infiltration (hvac) , gene rearrangement , dermatology , biology , lymphoma , gene , biochemistry , genetics , physics , thermodynamics
Syringolymphoid hyperplasia with alopecia is an uncommon skin disorder described in 1969 by Sarkany. Since then only three additional cases have been reported, all in the European literature. We present a 59‐year‐old man with two persistent hyperpigmented hairless patches of 13 years duration. Biopsy specimens revealed characteristic hyperplastic changes of the eccrine glands and ducts and a dense lymphocytic infiltrate surrounding eccrine structures with “syringotropism”. Perifollicular lymphocytic infiltration and changes consistent with follicular mucinosis and mycosis fungoides were also present. Imunophenotyping and gene rearrangement studies showed I he cells to be primarily of the T helper phenotype with rearrangement of I he surface receptor gene. Tomaszewski M‐M, Lupton GP, Krishnan J, Welch M, James WD. Syringolymphoid hyperplasia with alopecia: A case report.