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Eccrine angiomatous hamartoma (nevus):
Author(s) -
Sulica R. Lucien,
Kao Grace F.,
Sulica Virginia I.,
Penneys Neal S.
Publication year - 1994
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1994.tb00694.x
Subject(s) - pathology , medicine , apocrine , hamartoma , carcinoembryonic antigen , sweat gland , cd34 , nevus , anatomy , s100 protein , immunohistochemistry , biology , sweat , melanoma , cancer , stem cell , cancer research , genetics
Eccrine angiomatous hamartoma (nevus) is a rare form of congenital tumorous malformation with proliferation of eccrine secretory coils and duels, surrounding capillary angiomatous channels and occasionally oilier minor elements. To date, there have been only about 24 cases reported in the literature. We report an additional case with more detailed description of the microscopic Endings, including immunohistochemical observations. The patient was a 28‐year‐old female who presented with painless, flesh to reddish brown‐colored, violaceous or bluish subcutaneous nodules on the extremities and trunk. The tumors did not show sweating following exertion. The histologic features were comparable lo the previously reported cases. The hamartomatous eccrine sweat glands and duels and a few apocrine glands demonstrated qualitatively diminished antigens commonly found in the eccrine sweat apparatuses, such as carcinoembryonic antigen (CEA) and S–100 protein. The. findings of CD34, CD44, human nerve growth factor receptor and Ulex europacus antigens have not been previously reported. The histologic features suggested a “hamartomatous” growth rather than a true neoplastic process.