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T lymphocytes bearing the γ/δ T‐cell receptor in cutaneous lesions of dermatitis herpetiformis
Author(s) -
Kell Donna L.,
Glusac Earl J.,
Smoller Bruce R.
Publication year - 1994
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1994.tb00282.x
Subject(s) - dermatitis herpetiformis , pathogenesis , cd8 , pathology , medicine , dermal papillae , t cell , immunology , disease , immune system , hair follicle
T lymphocytes bearing the γ/δ T‐cell receptor are a rare component of normal human GI epithelium and skin. Recently, however, an unusually high percentage of T lymphocytes with γ/δ receptors has been described in gastrointestinal biopsies from patients with dermatitis herpetiformis, implicating the γ/δ T cell subset in the pathogenesis of this disease. We investigated a possible role for this subset of lymphocytes in the pathogenesis of the cutaneous lesions of dermatitis herpetiformis. Using a standard immunoperoxidase technique, we labelled perilesional skin biopsies from patients with dermatitis herpetiformis and other inflammatory dermatoses with monoclonal antibodies to CDS, CD4, CDS, α/β T cell receptor, γ/δ T cell receptor, and IL‐2 receptor. We found no differences in the percentage of γ/δ positive T lymphocytes in skin lesions of dermatitis herpetiformis as compared to other selected in‐flammatory conditions. These findings suggest that die pathogenesis of the cutaneous lesions of dermatitis herpetiformis is not mediated through γ/δ T cells, and that the cutaneous lesions may develop through mechanisms different from those operative in the gastrointestinal tract.

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